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As illustrated in Figure 12, the initial step Equilibration is a necessary step in reversed phase separation column under suitable conditions such as a (pH, ionic strength and polarity)

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Furthermore, the expression of the transcription factor p53 and the cyclin-dependent kinase inhibitor p21 induced by bilirubin inhibits the proliferation of established smooth muscle cells (SMC) and neoplastic endothelial proliferation (104, 105)